Butyrate Specifically Down-Regulates Salmonella Pathogenicity Island 1 Gene Expression
نویسندگان
چکیده
منابع مشابه
Sigma32-mediated negative regulation of Salmonella pathogenicity island 1 expression.
Salmonella pathogenicity island 1 (SPI1) enables infecting salmonellae to invade the intestinal epithelium and induce a proinflammatory response and macrophage cell death. SPI1 expression is controlled by a complex cascade with several transcriptional regulators within the island and global regulators outside it. Previously, we reported that DnaK-depleted salmonellae could neither invade epithe...
متن کاملFur regulates expression of the Salmonella pathogenicity island 1 type III secretion system through HilD.
The invasion of intestinal epithelial cells by Salmonella enterica serovar Typhimurium is mediated by a type III secretion system (T3SS) encoded on Salmonella pathogenicity island 1 (SPI1). Expression of the SPI1 T3SS is tightly regulated by the combined action of HilC, HilD, and RtsA, three AraC family members that can independently activate hilA, which encodes the direct regulator of the SPI1...
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Salmonella enterica serovar Typhimurium causes self-limiting gastroenteritis in humans and a typhoid-like disease in mice that serves as a model for typhoid infections in humans. A critical step in Salmonella pathogenesis is the invasion of enterocytes and M cells of the small intestine via expression of a type III secretion system, encoded on Salmonella pathogenicity island 1 (SPI-1), that sec...
متن کاملThe Salmonella pathogenicity island-1 type III secretion system.
Salmonella pathogenicity island 1 (SPI1) encodes a type III secretion system that is required for virulence during the intestinal phase of infection. The expression of SPI1 genes is controlled by many global regulatory pathways that affect the expression/activity of transcriptional regulators encoded on SPI1.
متن کاملMlc regulation of Salmonella pathogenicity island I gene expression via hilE repression
The global regulator Mlc is a repressor of several genes and operons that are involved in sugar uptake and metabolism. A Salmonella enterica serovar Typhimurium mlc mutant showed reduced levels of invasion and cytotoxicity compared to the wild-type, and exhibited reduced expression levels of hilD, hilA and invF, which are regulatory genes in the Salmonella pathogenicity island 1 (SPI1). However...
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ژورنال
عنوان ژورنال: Applied and Environmental Microbiology
سال: 2006
ISSN: 0099-2240,1098-5336
DOI: 10.1128/aem.72.1.946-949.2006